Use of immunoregulatory cells in stem cell transplantation reviewed.

2003 DEC 18 - (NewsRx.com & NewsRx.net) -- The use of immunoregulatory cells in stem cell transplantation has been reviewed.

"Various immunoregulatory cells that inhibit graft-versus-host disease (GVHD) and induce the graft-versus-leukemia (GVL) effect are found after allogeneic hematopoietic stem-cell transplantation," hematologists in Japan explained. "These cells comprise CD4(+)CD25(+) regulatory T-cells, regulatory dendritic cells (rDCs), gammadelta T-cells, natural killer (NK) T-cells, and NK cells and T-cells with inhibitory NK receptors."

"Although the first four types of cells effectively inhibit GVHD in animal models, with rDCs showing an inhibitory …